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Are you fucking with me 

It's like are you kidding me, but more extreme
Lauren is walking and steps in dog shit and yells are you fucking with me
Are you fucking with me by jewelsd October 15, 2019

Who are you, and what have you done with 

Used to express astonishment when somebody says or does something completely out of character. The only possible explanation is that they've been replaced by an alien shape-shifter who looks exactly like them, but acts differently.

The phrase is a parody of the cliché found in old movies, when somebody returns home to find their lover gone and a stranger in their place.
Shanee: "I'm going to stay in tonight and study."
Ruthie: "Who are you, and what have you done with Shanee?"

Are you gonna go A.D., or are you sticking with B.C.? 

A question that asks if a society or group is going to join the modern era (A.D.) with technology and advanced ethics or if they are going to live in the Bronze Dark Ages (B.C.) with immoral values such as stoning people to death. A choice between embracing the modern world fully rather than keeping one hand on advanced technology while being barbaric with the other hand. The choice to advance all aspects of a society rather than just the military. Modernization of only some aspects of a society doesn't mix with keeping backwards with the rest, as it just doesn't work.
"It comes down to this Iran, you have a choice to make. do you want the world to be comfortable with you having nuclear weapons or are you going to keep stoning people? Are you gonna go A.D., or are you sticking with B.C.? Cause you're not allowed to be that modern and that primitive at the same time! You have to choose, they don't work together. It's the reason you never see anyone riding a Segway with Fred Flintstone Wheels."- Jon Stewart, The Daily Show, 8th September 2010.

Are you down with me? 

Him: "Come over. Are you down with me?"
Her: "Of course. I'll be there in 5"

what are you DOING with your life?

Means the same thing as:
What is WRONG with you?
Are you STUPID?
Are you HIGH?

Basically used if you don't understand how someone could ask a really stupid question.
Or if they will not leave you alone.
Girl 1: The sun goes around the Earth, right?

Girl 2: OhmiGAWD what are you DOING with your life?

Boy: keeps taking girl's phone while she's working

Girl: "Fucking knock it off!"

Boy: puts phone back on table, waits a few seconds & looks away, then takes phone again

Girl: Wrestles with boy for her phone "Oh my effing god, what are you DOING with your life?!"

are you being intimate with someone? 

Girl -may I ask you a question? Guy -Sup? Girl-Are you being intimate with someone? Guy- No I am not.