twatknob Share definition Flag The term used to offend someone by calling them a vagina and a penis, at the same time. Megan : Oh my god ! Georgina is such a twatknob. Hayley : I know, i can't believe her! twatknob by supergirl2k11 May 13, 2011 0 0 Get merch Get the twatknob mug. Buy Now — $32.95 See more merch