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A drink composed of cough medicine with codeine, liquor, and a jolly rancher.
"Sippin' on some syzurp"
syzurp by Dreamslost December 26, 2008
Syzzurp is an intoxicating beverage whose ingredients vary depending on personal preference. The original syzzurp is "Phenergan VC with Codeine" syrup mixed with sprite for flavor. Intoxication comes from an antihistamine (promethazine) and a narcotic (codeine) that are present in the syrup.

Due to the fact that this particular syrup is available by prescription only, it isn't easily obtainable in a lot of cases. So people come up with their own recipe to emulate the original. One example is mixing crushed narcotic pills (such as percocet or vicodin) into sprite with varying amounts of "Nyquil Cough". This combination produces roughly the same effects as the original. It also has the potential to be a much different experience over-all due to dextromethorphan (cough suppressant) being present in Nyquil. At higher than therapeutic doses, dextromethorphan has the ability to produce a very intense "trip" of its own.

These "emulated syzzurps" can also be a lot more dangerous as well. There are many different combinations of active ingredients in different cough syrups which make this a dangerous situation for those uneducated on the subject. Compound that with the fact that many people prefer to use varying amounts of alcohol in the mixture, and you have the potential for disaster.

However, for those who know what they’re doing, the resulting intoxication is extremely pleasurable. There’s the possibility for many different effects depending on the ingredients the consumer decides to use. But the primary sought-after effects are sedation and euphoria. Some people like to put jolly ranchers in their syzzurp. Some proclaim that it must be consumed from a Styrofoam cup. Some like it with a little Hennessey mixed in. But one thing is for sure… “Syzzurp” is NOT just one single concoction. It’s a term used to identify any narcotic-containing cough syrup that’s mixed with sprite and/or other various ingredients.
Damn son, that syzzurp's got a nigga straight leanin'!
syzzurp by ike eyes September 18, 2008
A drink made with cough syrup, jolly ranchers, sprite, and hennessy.
sippin' on some syzzurp
syzzurp by rain February 24, 2003
Prescription narcotic cough syrups. Most contain Hydrocodone or Codeine. These syrups have other ingredients in them for treating cold and cough symptoms, such as Antihistamines or Decongestants.

Some Common Formulas:
Tussionex- 10mg Hydrocodone (Extended-Release) and Chlorpheniramine 8mg per 5ml (1 tsp.)
Codiclear/Hycotuss- Hydrocodone and Guaifenesin
Lortab Elixir- Hydrocodone and Acetaminophen
Prometh VC with Codeine: Codeine and Promethazine

Often people will add Alcohol, Flavorings (ex. Kool-Aid), or crushed-up pills (such as Vicodin) to potentiate the effects of the syrup or make it taste better.

A somewhat common misperception is that Sizurp refers to over-the-counter cough syrups containing DXM (dextromethorphan) which some abuse ("Robotrippin") for its dissassociative effects.
From Three Six Mafia, Sippin on Some Sizzurp:

"I got the wet promethazine, thick orange & yellow tuss
Hydroco-done...Sippin on Some Sizurp..."
Sizurp by WSB15 April 11, 2006

South Side Syzurrp 

South Side Syzurrp is a drink created by three brave men living in south Evanston, IL. It is an alcoholic beverage, the recipe for which is as follows.

(Makes ten to fifteen servings)
1. Take empty milk cartoon and write South Side Syzurrp on the outside.
2. Pour between 2/3 and a whole handle of vodka in (depending on the mood).
3. Add one carton of Welch's Mango Twist.
4. Add one small package of Crystal Light Pink Lemonade
5. Fresh squeezed lemon juice (anywhere from 1 to 4 is acceptable).
6. Fill the rest of the container with a second carton of Welch's.
Drink to your hearts content.
Next weekend we bought to be on that South Side Syzurrp.
n.
1. An illegal effervescent cocktail beverage consumed by hoods.
a. Recipe: One part strawberry soda (8oz), one part cough syrup (Dextromethorphan HBr), one teaspoon crushed codeine. Shake mixture well; drink cold.

b. Recipe (optional): One part cough syrup (Dextromethorphan HBr), one part ginger ale soda.
Sizurp by Matt Hoyt February 10, 2004
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