Syzzurp is an intoxicating beverage whose ingredients vary depending on personal preference. The original syzzurp is "Phenergan VC with Codeine" syrup mixed with sprite for flavor. Intoxication comes from an antihistamine (promethazine) and a narcotic (codeine) that are present in the syrup.

Due to the fact that this particular syrup is available by prescription only, it isn't easily obtainable in a lot of cases. So people come up with their own recipe to emulate the original. One example is mixing crushed narcotic pills (such as percocet or vicodin) into sprite with varying amounts of "Nyquil Cough". This combination produces roughly the same effects as the original. It also has the potential to be a much different experience over-all due to dextromethorphan (cough suppressant) being present in Nyquil. At higher than therapeutic doses, dextromethorphan has the ability to produce a very intense "trip" of its own.

These "emulated syzzurps" can also be a lot more dangerous as well. There are many different combinations of active ingredients in different cough syrups which make this a dangerous situation for those uneducated on the subject. Compound that with the fact that many people prefer to use varying amounts of alcohol in the mixture, and you have the potential for disaster.

However, for those who know what they’re doing, the resulting intoxication is extremely pleasurable. There’s the possibility for many different effects depending on the ingredients the consumer decides to use. But the primary sought-after effects are sedation and euphoria. Some people like to put jolly ranchers in their syzzurp. Some proclaim that it must be consumed from a Styrofoam cup. Some like it with a little Hennessey mixed in. But one thing is for sure… “Syzzurp” is NOT just one single concoction. It’s a term used to identify any narcotic-containing cough syrup that’s mixed with sprite and/or other various ingredients.
Damn son, that syzzurp's got a nigga straight leanin'!
by ike eyes September 14, 2006
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A drink made with cough syrup, jolly ranchers, sprite, and hennessy.
sippin' on some syzzurp
by rain February 24, 2003
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" Dats that Surp mutha fucka, dats dat surp"
by 'Surp' October 10, 2003
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1. That old school sprite drank we used to sip on in the hood.
2. That new school purple drink that Cam'ron put out...That stuff's the shit...Chrystal my ass
"You 'aint drunk nigga, you 'aint drunk nigga, 'till that Syzzurp and Henny is in your cup nigga."
-P. Diddy
by Roccccc September 23, 2005
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