A word used to describe something that is sickeningly adorable, cute, or charming. Examples of "cutesy-patootsie" objects are puppies, kittens, Pikachu, or young children---genearlly something fuzzy and cuddly.
Ugh, that little kid is so cutesy patootsie, it makes me sick.
I wish she would stop acting so cutesy patootsie, it's reallygetting to my nerves.
An act or being so unbearably cute that you just want tosqueeze the individual acting in a cutsey patootsey manner.
When Jess laughs at her own jokes, bikes across Biarritz after drinkinga bottle of wine in search of tequila, or gets annoyed when Alex tickles her nose with her hair, she is being a cutsey patootsey.