When you're taking a situation as it comes and flying by the seat of your pants. Often attributed to anxiety, and feelings either good or bad. A reference to clinging fiercely to something, such as a rope, to the point where ones knuckles would turn white from forcing blood from the capillaries.
"Yo, bra, why's your hand in a cast?"
"I broke it knucklin' your momlast night."
-or-
"Why are you walking so messed up, were you riding a horse?"
"Naw man, I spent last night getting knuckled by 8 dudes and now my ass is broken like Angel's face from Fight Club."
Barbaric way to impregnate a woman. The correct method would involve firstly restraining a woman. Next a male will proceed to orgasm onto his fist where he will punch the female in the vagina. Repeat with fresh cum every 2-3 hits to insure efficiency on this most delicate of procedures.