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Isot stands for Island in the Sea of Time. It references a novel where an island in relatively recent times is taken from it's time and place, and placed in the distant past, creating an alternate history. The acronym is popular on the alternate history forum.
What if Darth Vader were ISOTed into Anakin just after his nightmares about his mother started?
isot by JunAhrkSonaak November 18, 2017
Related Words

imothate 

to mock someone's expected reaction, rather than something already said or done

a portmanteau of "hypothetically imitate"
"I can't wait to see my sister when she finds out who was with Mike last night"
"OH MY GAWD I TRUSTED YOU BITCH!"
"Hahaha that's great...even I can't imothate her that well"
imothate by atds March 19, 2008
Andy: Hey man, torrentbox is awsome

Tom: HAHAHA isohunt pwns torrentbox and every other torrent search engine.
isohunt by keylikesfood December 12, 2006
Another name for timothy

Also is short for Dak Prescott isn’t worth $40 million a year.
Imoth is so cool
Imoth by FOLESNICKY June 8, 2020

Isotoners 

A outdoor rubber glove, used for gardening and yard work. The brand of gloves OJ couldn't fit on his hands during his murder trial.
Joe: I'm thinking of getting these isotoners to do some yard work

Bob: Good idea, plus if you kill someone and they get wet they'll shrink and you'll be acquitted.
Isotoners by Randyt13 June 22, 2013
Each element has many versions that contain a different number of neutrons in the nucleas. Each different version of the element is called an isotope.
Carbon-13 is and isotope of Carbon
Isotope by PrivateDonut February 10, 2005