if you check out the "e" meaning in urban dictionary, this is pretty much the same, BUT, e- i when you see something out of place, thats when you say "e-"
The greatest meme of all time. A deep fried picture of Lord Farquad with markiplier's face photoshopped on it, with the single letter "E" in impact font at the bottom. It is nihilism in it's purest form, and proof that every day we stray further from god.
A meme that was first used on a deep fried image of Markiplier's face photoshoped on Lord Farquadd's head. The E meme itself doesn't mean anything. It's just made to confuse other people.