It's a catch phrase dating back to 1887, when, in a blatant case of favoritism, British Prime Minister Robert Cecil (a.k.a. Lord Salisbury) decided to appoint his nephew Arthur Balfour to the prestigious and sensitive post of Chief Secretary for Ireland.
So "Bob's your uncle" is another way of saying "your success is guaranteed."
You just put these parts together like this, and Bob's your uncle - you have a working model!
You want to go to the stadium? Go straight on until you reach the park, take the first left, and Bob’s your uncle - you're there!
A homer fan who frequents a rival sports team's fan site (e.g. orangemane.com), and who:
1. Spreads optimistic lies about his own team even though the obvious evidence of massive failure has been cascading down around him and his team for decades;
2. Lives in his mother's basement (even though she lives in a trailer),
3. Has never held a steady job, unless you count buying and selling Star Wars memorabilia on eBay a steady job,
4. Has never, ever kissed a girl he isn't related to and likely never will.
You're moving to Kansas City? Dude, there nothing more pathetic than that. That's totally Bob's Your Information Minister.