A phrase that is utilized to express positiveness, a guarantee, or just general "knowing" of a person, subject, or event.
Jake: "Was the party at TJ's really as cool as everyone said it was?"
Dre: "Hell yeah man. Everyone was having a good time."
Jake: "Man, for real? And I missed it?!"
Dre: "Rest Assured Jake. You missed more than you'll ever know..."
The recognition that the use of nuclear weapons between any two nuclear powers (or nuclear-allied powers) will result in mutual destruction. The reason nuclear weapons are so useful (and can never be used).
Mutually Assured Destruction guarantees that nobody but those crazy Arabs will ever use nukes.