A phrase that is utilized to expresspositiveness, a guarantee, or just general "knowing" of a person, subject, or event.
Jake: "Was the party at TJ's really as cool as everyone said it was?"
Dre: "Hell yeah man. Everyone was having a good time."
Jake: "Man, for real? And I missed it?!"
Dre: "Rest Assured Jake. You missed more than you'll ever know..."
The recognition that the use of nuclear weapons between any two nuclear powers (or nuclear-allied powers) will result in mutual destruction. The reason nuclear weapons are so useful (and can never be used).