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The combined names "Buffy" and "Spike," as seen on Buffy: The Vampire Slayer.

Normally used to describe a fanfiction written about their relationship.
I just read this great spuffy piece.
spuffy by iamgoose2 July 30, 2004
Related Words
Spulfy spuffy SPÜLF Spully
The couple Spike, a vampire, and Buffy, the slayer, from the Buffy The Vampire Slayer series. Spike fell in love with Buffy and got his soul back for her. Spuffy is the couple with the most unique storyline, best chemistry, and hottest sex scenes.
Spuffy is the best couple ever to appear on TV!
Spuffy by Jessgurl July 3, 2005
Term coined to describe the love/hate relationship between "Spike" and "Buffy", two characters played by James Marsters and Sarah Michelle Gellar in the hit series "Buffy The Vampire Slayer".

It is typically used as an adjective in normal conversation to exemplify traits exhibited in their on-screen relationship.
"Our relationship was very spuffy."
spuffy by Darren Coleman October 13, 2003
A relationship, or ship, name for the couple Spike and Buffy from the TV show Buffy the Vampire Slayer (BTVS) that originally aired in 1997.
Spuffy is so cute; I ship them!
Spuffy by toospiffy4you May 25, 2015
Used when referring to the couple Spike and Buffy from Buffy the Vampire Slayer
Spuffy scenes are the best.
Spuffy by Alexa October 12, 2004
Adverb, meaning "not thirsty".

Apart from its original form, literally meaning that you are full/not thirsty, it can be used in different contexts as slang.

The word descends from Norwegian slang. However it functions well in other languages, such as English, German, Chinese, etc...

e.g:
Getting spulf: drink until you are totally not thirsty/getting drunk.
A spulfer: a person who really enjoys getting spulf.
A spulfie: a girl who has swallowed her share of seamen.
- Would you like some more tea, Ms. Yovankizha?

- No thank you, I'm spulf

- Do you think I have a shot at Lisa? She's totally super hot!
- Na, man... She's spulf when it comes to sex..

- Dude! I'm so glad school is over!
- Hell yes! We're getting spulf this weekend, for sure!

- Did you see how Steve kept puking all over the place last night?
- Yeah, I know.. He just kept drinking although he was spulf hours ago.. He is a real spulfer..!
Spulf by Spulfer June 5, 2009