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The combined names "Buffy" and "Spike," as seen on Buffy: The Vampire Slayer.

Normally used to describe a fanfiction written about their relationship.
I just read this great spuffy piece.
by iamgoose2 July 30, 2004
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Sep 17 Word of the Day
Fredagsmys is pretty much the most holy tradition of Sweden. The word origins from two words; β€œfredag” and β€œmys”, which roughly translates to Friday and cozy. Every Friday, all Swedes drive by the supermarket to buy ingredients for taco, soda and chips. Then, they all sit down in their sofas with their families or friends and watch telly. Usually, the parents fall asleep after a few glasses of wine or beer while the kids stuff themselves with chips until they have a stomach ache.
Now it's the end of the week; it is time for fredagsmys!
by popsicle power June 19, 2011
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The couple Spike, a vampire, and Buffy, the slayer, from the Buffy The Vampire Slayer series. Spike fell in love with Buffy and got his soul back for her. Spuffy is the couple with the most unique storyline, best chemistry, and hottest sex scenes.
Spuffy is the best couple ever to appear on TV!
by Jessgurl June 21, 2005
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Term coined to describe the love/hate relationship between "Spike" and "Buffy", two characters played by James Marsters and Sarah Michelle Gellar in the hit series "Buffy The Vampire Slayer".

It is typically used as an adjective in normal conversation to exemplify traits exhibited in their on-screen relationship.
"Our relationship was very spuffy."
by Darren Coleman October 13, 2003
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Used when referring to the couple Spike and Buffy from Buffy the Vampire Slayer
Spuffy scenes are the best.
by Alexa October 12, 2004
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A relationship, or ship, name for the couple Spike and Buffy from the TV show Buffy the Vampire Slayer (BTVS) that originally aired in 1997.
Spuffy is so cute; I ship them!
by toospiffy4you May 23, 2015
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Spuffy is a common name given to pet raccoons due to their propensity for constant masturbation.
John D "Dude...did you here that Ben got a pet raccoon?! He called it Spuffy"
John G "Ahhh! That explains the stains on the walls"
by Cpt Brownsauce Sandwich December 15, 2009
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