A "Skunktail"(suppository pill filled with kief) laced with PCP, LSD, Roofalin, and over-the-counter laxatives. Rendering the victim helpless, paranoid, disassociated, and covered in feces. Spikers are used to achieve a drug facilitated sexual assault. Spiker became a household name when several Bathhouse visitors came forward in the mid 90's of being sexually assaulted.

It's also been known as "spiking" and/or "getting spiked".

When you eat dirt for the first time and leave your family to build a shack in the woods

A dual-wieldable gun in Halo 3.
Shoots spikes, hence the name.

A "spiker" is a rogue pubic hair that takes on the persona of an extremely hard piece of cotton (or even fishing twine) that has set up house in the front part of your undies. And usually makes an appearance when one is in a public place. Creating an irresistible urge to scratch your groin.

1.) Someone with an unnatural compulstion to wear spikes and all things metal on all parts of their body. Often associated with maschisocism. Very sexy on girls.
2.) Someone who spikes people's drinks at a party, I.E: Adding drugs/alcohol to them for fun or profit.
3.) Madman (my buddy, not the admin) on a really fucking bad day.