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A class of drug (Selective Serotonin Reputake Inhibitor) designed to 'treat' depression, though there is no real evidence that these drugs work beyond temporary stimulation, numbing, placebo effect, or a combination of such. Remember, the 'treatment' of mental illness is highly subjective and is not well understood, making it an easy gray area to screw around with for profit. The 'clinical results' have been fudged by the pharmaceutical companies (who test the drugs themselves) and the FDA, and what little reliable information left obfuscated by nondescript language and misrepresentation. There are many dangerous side effects which have been reported, and are also underplayed purposely to boost sales. In reality, we understand very little about the nature of Serotonin and the brain, so giving SSRI's to 'depressed' patients is simply a stab in the dark to avoid dealing with real issues at hand.
Depressed? It can't be because you feel helpless in a world where the only real choices available to work for a dispassionate corporation or suffer on the street. It can't be because you never felt connected to anyone. It can't be because you were abused at home! No! It's biological! I swear! I'm a real scientist, and I'm just pulling shit out of my ass, but my white lab coat and nondescript brain scan means I'm right! Seriously! Here, take these potentially dangerous and useless drugs! They're called SSRI's! And you really need to want it to help, because that's the only way it will! Wait it's just a placebo effect, but don't tell anyone, and if you do I'll give you more drugs to help treat your 'problems with authority'.
ssri by Shadow Creator October 20, 2007
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Selective Serotonin Reuptake Inhibitor - a 'class' (different 'classes' treat different things) of antidepressant medication.
Prozac, Zoloft and Lexapro are all SSRI's.
SSRI by Frin March 18, 2006
Related Words
ssri stands for selective serotonin reuptake inhibitor. they are a class of antidepressants commonly taken to treat depression and anxiety. examples include prozac, zoloft, and lexapro.

many men who take these medications feel no side effects except for the universal one: ssris make men take an extremely long time to cum during sex. it usually takes about 30 minutes or more. though this can be nice for the girl, it is usually frustrating for the guy as they might not be able to cum at all during sex.

If combined with death grip, this can be fatal.
"Hey man, how did it go w Girl X last night?"

"She was hot but I got ssri dick so I couldn't finish."

"Fuck!"
ssri dick by deprwssedboi February 26, 2018

SSRI victim

A person with persistent, possibly permanent, sexual incapacity -- inability to achieve either erection or orgasm, or drastically reduced libido -- due to the side effects of SSRI antidepressants.
Uh, hon, you might think twice about going with that SSRI victim -- if you want a sex life, that is.
SSRI victim by DancingKali May 30, 2011

SSRI spinster 

A woman who has knowingly lost interest in sex due to the use of SSRI anti-depressants.

Oftentimes, these women are fully aware of the fact that the SSRI's have eliminated, or sharply reduced their libido, but they don't care, some women even see a reduction of sexual urges as being beneficial.
CHICK ---- Every since I started taking Lexapro I don't feel so miserable and I'm better at my job now, but I could care less about sex.

DUDE (Chick's soon-to-be-ex-boyfriend) --- You feel BETTER now that your not having sex with me? That's just great..

CHICK ---- It's not that I dislike sex with you, I just don't care, why bother?

DUDE --- Why bother? No sex will end our relationship!

CHICK ---- I'm in a better place with the Lexapro, I don't need your negative energy

DUDE --- You're an SSRI spinster...I can't be with you anymore
SSRI spinster by 415man94102 May 29, 2012

SSRI King 

a male or assigned-male-at-birth person who can fuck for a long time without orgasming due to the side effects of their antidepressant/anxiety medication
We fucked for hours and he never came—he’s a true SSRI King.

SSRI Clout 

A deranged lunatic who is suffering from psychiatric side effects of suicidal and homicidal ideation; decides to go on a killing spree to gain infamy
Luigi really seemed to lose it after he became depressed. Despite being a millionaire himself; he decided to go after that rich CEO looking to rack up his SSRI Clout.
SSRI Clout by FoslTheApostle December 21, 2024
More from Urban Dictionary

fache-couture 

French slang, which translated, means "bull's fashion" but basically equates to "hyper trendy" or overly trendy. Used when a person wishes to express distaste at the latest fashion trend/fad, because it seems that everyone has a certain item of clothing or is wearing it. This term is most frequently heard in Paris but is slowly spreading to other parts of France.
1. That Burberry scarf is so fache-couture.
2. That purple American Apparel hoodie is so fache-couture.
fache-couture by bkgmh46x0x March 18, 2008
Word of the Day on October 17, 2026
A slang term for GLP-1 medications(like Ozempic, Wegovy, Mounjaro, etc.), usually referring to their appetite-killing, weight-loss, or “I forgot to eat” effects rather than the medical details.

Usage:
* Often casual, ironic, or meme-y
* Can imply effortless weight loss, suppressed hunger, or being “powered by pharmaceuticals”

Notes:
Not a brand name—just shorthand for the whole GLP-1 wave. Frequently shows up in online jokes, gym talk, and group chats where people pretend they’re *totally* doing it naturally.
“I’m not dieting, I’m just on that glippy.”
“Ever since the glippy hit, food feels optional.”
“That summer body? Yeah, glippy assisted.”
Glippy by Wild Stoner Appears December 14, 2025
Word of the Day on October 16, 2026

fauxstalgia 

Faux nostalgia. Faking old things in an attempt to recapture the feeling of times gone past, especially of technology that has passed.
Hipstamatic pictures, just like the vinyl-static added to digital recordings, is prime fauxstalgia
fauxstalgia by scotte61 December 16, 2010
Word of the Day on October 15, 2026

pajama casual 

Pajama casual is a term used when working from home and preparing for a video conference. All business above the waist and your pajama pants down below.
We have a Zoom meeting in a few minutes and I’ll probably go pajama casual.
pajama casual by jrod-knows March 31, 2020
Word of the Day on October 14, 2026

funflation 

The recent boom in consumer spending on entertainment and experiences with a high demand running up the cost of enjoying of those experiences.
I’m trying to go to this Taylor Swift concert but the funflation has made it so impossible for me to afford tickets.
funflation by Dfree523 November 17, 2023
Word of the Day on October 13, 2026
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