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A class of drug (Selective Serotonin Reputake Inhibitor) designed to 'treat' depression, though there is no real evidence that these drugs work beyond temporary stimulation, numbing, placebo effect, or a combination of such. Remember, the 'treatment' of mental illness is highly subjective and is not well understood, making it an easy gray area to screw around with for profit. The 'clinical results' have been fudged by the pharmaceutical companies (who test the drugs themselves) and the FDA, and what little reliable information left obfuscated by nondescript language and misrepresentation. There are many dangerous side effects which have been reported, and are also underplayed purposely to boost sales. In reality, we understand very little about the nature of Serotonin and the brain, so giving SSRI's to 'depressed' patients is simply a stab in the dark to avoid dealing with real issues at hand.
Depressed? It can't be because you feel helpless in a world where the only real choices available to work for a dispassionate corporation or suffer on the street. It can't be because you never felt connected to anyone. It can't be because you were abused at home! No! It's biological! I swear! I'm a real scientist, and I'm just pulling shit out of my ass, but my white lab coat and nondescript brain scan means I'm right! Seriously! Here, take these potentially dangerous and useless drugs! They're called SSRI's! And you really need to want it to help, because that's the only way it will! Wait it's just a placebo effect, but don't tell anyone, and if you do I'll give you more drugs to help treat your 'problems with authority'.
ssri by Shadow Creator October 20, 2007
Urban Dictionary Merch
Selective Serotonin Reuptake Inhibitor - a 'class' (different 'classes' treat different things) of antidepressant medication.
Prozac, Zoloft and Lexapro are all SSRI's.
SSRI by Frin March 18, 2006
Related Words
ssri stands for selective serotonin reuptake inhibitor. they are a class of antidepressants commonly taken to treat depression and anxiety. examples include prozac, zoloft, and lexapro.

many men who take these medications feel no side effects except for the universal one: ssris make men take an extremely long time to cum during sex. it usually takes about 30 minutes or more. though this can be nice for the girl, it is usually frustrating for the guy as they might not be able to cum at all during sex.

If combined with death grip, this can be fatal.
"Hey man, how did it go w Girl X last night?"

"She was hot but I got ssri dick so I couldn't finish."

"Fuck!"
ssri dick by deprwssedboi February 26, 2018

SSRI victim

A person with persistent, possibly permanent, sexual incapacity -- inability to achieve either erection or orgasm, or drastically reduced libido -- due to the side effects of SSRI antidepressants.
Uh, hon, you might think twice about going with that SSRI victim -- if you want a sex life, that is.
SSRI victim by DancingKali May 30, 2011

SSRI spinster 

A woman who has knowingly lost interest in sex due to the use of SSRI anti-depressants.

Oftentimes, these women are fully aware of the fact that the SSRI's have eliminated, or sharply reduced their libido, but they don't care, some women even see a reduction of sexual urges as being beneficial.
CHICK ---- Every since I started taking Lexapro I don't feel so miserable and I'm better at my job now, but I could care less about sex.

DUDE (Chick's soon-to-be-ex-boyfriend) --- You feel BETTER now that your not having sex with me? That's just great..

CHICK ---- It's not that I dislike sex with you, I just don't care, why bother?

DUDE --- Why bother? No sex will end our relationship!

CHICK ---- I'm in a better place with the Lexapro, I don't need your negative energy

DUDE --- You're an SSRI spinster...I can't be with you anymore
SSRI spinster by 415man94102 May 29, 2012

SSRI King 

a male or assigned-male-at-birth person who can fuck for a long time without orgasming due to the side effects of their antidepressant/anxiety medication
We fucked for hours and he never came—he’s a true SSRI King.

SSRI Clout 

A deranged lunatic who is suffering from psychiatric side effects of suicidal and homicidal ideation; decides to go on a killing spree to gain infamy
Luigi really seemed to lose it after he became depressed. Despite being a millionaire himself; he decided to go after that rich CEO looking to rack up his SSRI Clout.
SSRI Clout by FoslTheApostle December 21, 2024
More from Urban Dictionary

murderhobo 

In a tabletop game, a murderhobo is a player who murders NPCs indiscriminately. This is normally derogatory, referring to a player who totally ignores quests, dialog, backstory, trade, world building etc.

The term is most common with Dungeons and Dragons, but it can be applied to most RPGs where the player is allowed to kill most quest-giving NPCs and NPC traders. E.g. Elder Scrolls, Fallout, Divinity original sin.
DM: The sad little orphan girl tugs at Steve's trenchcoat to get his attention, and ask for help saving her pet dog from...
Steve: I'd like to roll a strength check against strangling the orphan.
Dave: I call dibs on the dog.
DM: You murderhobos disgust me.
murderhobo by Loup&S September 9, 2021
Word of the Day on September 22, 2026
In sales terms, a whale is a prospect that is significantly larger than an organization’s average customer.

Whales are large and extremely difficult to close. Due to their immense size, they are highly sought-after.

A whale is typically identified at first by a whale hunter on the sales team, but often requires cross-discipline participation in order to close; this includes assistance from operations, engineering, creative, client success, and business development teams.
"Shit...the sales director chewed me out on the sales call this morning. He's totally pissed that I have nothing in my pipeline. I've been focused on this one whale for so long that I haven't had time to prospect for normal-sized deals."
Whale by FQ_GFY February 3, 2020
Word of the Day on September 21, 2026

Concrete cowboy 

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Eugene: Look at that dude in the cowboy hat!
Todd: He's just a concrete cowboy.
Word of the Day on September 20, 2026
any hard liquor that is cheap & potent.. eg. relska, popov, potters, evan williams, kamchatka, fireball, rumpleminze, southern comfort, everclear
hey let's get a drink of that?

go ahead
*takes drink* ugh wtf is that?

everclear & bepsi
fucking hobo loko eeessshh
hobo loko by d i z k o 2 0 8 September 14, 2026
Word of the Day on September 19, 2026

God Shot 

A chance happening with profound meaning, an unexpected blessing, a "sign".
Dr. Drew on Celebrity Rehab said "All of a sudden what had been just another Hollywood proposal became for him an unexpected blessing, an opportunity for growth. In drug recovery language, that's called a "God shot."
God Shot by Imogen1564 February 25, 2011
Word of the Day on September 18, 2026
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