A class of drug (Selective Serotonin Reputake Inhibitor) designed to 'treat' depression, though there is no real evidence that these drugs work beyond temporary stimulation, numbing, placebo effect, or a combination of such. Remember, the 'treatment' of mental illness is highly subjective and is not well understood, making it an easy gray area to screw around with for profit. The 'clinical results' have been fudged by the pharmaceutical companies (who test the drugs themselves) and the FDA, and what little reliable information left obfuscated by nondescript language and misrepresentation. There are many dangerous side effects which have been reported, and are also underplayed purposely to boost sales. In reality, we understand very little about the nature of Serotonin and the brain, so giving SSRI's to 'depressed' patients is simply a stab in the dark to avoid dealing with real issues at hand.
Depressed? It can't be because you feel helpless in a world where the only real choices available to work for a dispassionate corporation or suffer on the street. It can't be because you never felt connected to anyone. It can't be because you were abused at home! No! It's biological! I swear! I'm a real scientist, and I'm just pulling shit out of my ass, but my white lab coat and nondescript brain scan means I'm right! Seriously! Here, take these potentially dangerous and useless drugs! They're called SSRI's! And you really need to want it to help, because that's the only way it will! Wait it's just a placebo effect, but don't tell anyone, and if you do I'll give you more drugs to help treat your 'problems with authority'.
by Shadow Creator October 4, 2007
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Selective Serotonin Reuptake Inhibitor - a 'class' (different 'classes' treat different things) of antidepressant medication.
Prozac, Zoloft and Lexapro are all SSRI's.
by Frin March 6, 2006
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ssri stands for selective serotonin reuptake inhibitor. they are a class of antidepressants commonly taken to treat depression and anxiety. examples include prozac, zoloft, and lexapro.

many men who take these medications feel no side effects except for the universal one: ssris make men take an extremely long time to cum during sex. it usually takes about 30 minutes or more. though this can be nice for the girl, it is usually frustrating for the guy as they might not be able to cum at all during sex.

If combined with death grip, this can be fatal.
"Hey man, how did it go w Girl X last night?"

"She was hot but I got ssri dick so I couldn't finish."

by deprwssedboi February 25, 2018
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A person with persistent, possibly permanent, sexual incapacity -- inability to achieve either erection or orgasm, or drastically reduced libido -- due to the side effects of SSRI antidepressants.
Uh, hon, you might think twice about going with that SSRI victim -- if you want a sex life, that is.
by DancingKali May 4, 2011
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A woman who has knowingly lost interest in sex due to the use of SSRI anti-depressants.

Oftentimes, these women are fully aware of the fact that the SSRI's have eliminated, or sharply reduced their libido, but they don't care, some women even see a reduction of sexual urges as being beneficial.
CHICK ---- Every since I started taking Lexapro I don't feel so miserable and I'm better at my job now, but I could care less about sex.

DUDE (Chick's soon-to-be-ex-boyfriend) --- You feel BETTER now that your not having sex with me? That's just great..

CHICK ---- It's not that I dislike sex with you, I just don't care, why bother?

DUDE --- Why bother? No sex will end our relationship!

CHICK ---- I'm in a better place with the Lexapro, I don't need your negative energy

DUDE --- You're an SSRI spinster...I can't be with you anymore
by 415man94102 March 1, 2012
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