The shortened way of saying 'for fuck's sake'. Just saying sakes is a very simple way to get your point across when something is wrong or if you are angry. Sakes
It means the same as for Christ's sake! but please note the spelling & syntax.
{John}: Hey Josh, quick! Check out that blimp about to crash into a radio tower!
{Josh}: For Christ sakes John, that looks just like the pictures of the Hindenburg crash that I've seen!!!
Used as a general term of exclamation or surprise similar to oh my lord, or oh my goodness, or oh shit. Mostly used by people in the 1930's, 1940's, and 1950's. Possibly a minced oath (softened form of swearing) substitute for "For the Lord's sake."
See also land sake.
Land sakes alive, my grandmother said. That sure was a swell sunset.