Derived from the italian suffix -issimo, meaning "extreme" or "remarkable" and the english root penis, penissimo means an extremely large or remarkable penis, one that is pleasing to the eye, and a woman.
Damn your penissimo is huge! I bet you get all the ladies.
The word itself has many uses and can be used as a verb or a noun.
n. A penishizzle, in some circles, has come to be known as an extremely large, awesome, and studd-like penis.
v. To be none other than owned in the male reproductive organs.
n. Dear Lord! Edgar's penis is simply pathetic... He definitely does not have a Penishizzle!
v. Dude... Jettman totally penishizzled Ryan, right in front of Checkers!