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It is 'furry noise' combined with the sound of dying in the netfamous Roblox game. It means 'oh no' or you say it when something sad happens.

You can only decide it by knowing the rest of the monolog.
-so i met a nice girl yesterday
-Oh yeah?
-but it turned out that she wasn't into furrys.. I can't find a real relationship tho, maaan
- Well, owoof man. You'll find somebody one day bro. Don't worry
Owoof by Cameherefromdiscordohno November 17, 2018
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owofujiowo

A stupid furry that exists in the face of the planet'
other names:
tofu_fuji (PSN)
fujilolfuji (e621)
senor_fujles (Instagram)
Person 1: Hey, owofujiowo posted on his instagram!

Person 2: who the fuck is that?
owofujiowo by owofuji February 21, 2022
You see those guys over there. The Venice Hoodlums they are OWOF
OWOF by Bluesman7 January 20, 2011
1. (Good oooffff) : When a woman is so fine that you can’t get anything out of your mouth except an “Oooffff”.
2. (Bad oooffff) : A reaction to anything that makes you feel true utter disgust.
1. *Sees a woman that acknowledges you and is hotter than your girlfriend* “Oooffff”.

2. “Hitler was such an amazing person” .... “Oooffff”...
The sound everyone makes when they die
*Man dies* "ooof"
Ooof by BigBoiBorris February 10, 2018
when you mess up majorily.....YOUVE OOOFED
Timmy: I slept with your mom

Larry: Bro thats my Grandma

Timmy: OOOOF
OOOF by NICK GRR July 29, 2018
When a normal OOF isn’t enough you just gotta OOOF
Person #1: yeah my dog died

Person #2: *panics on what to text* OOOF
Person #1: thanks for listening
OOOF by Is this the real life October 27, 2018