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Variant of "Oh no!", used sarcastically to indicate that what is being referred to is NOT, in fact, something to be alarmed about.
"My World of Warcraft server's economy is ruined! I can now only sell Arcane Crystals for 7 gold coins apiece, whereas before I could sell them for 8."

"Oh noes!"
oh noes! by Roger M. Wilcox April 19, 2007
3 little girls are on a tube ride in their local lake. They hit a monster wave, and all 3 of them fly off of the rub screaming oh noes!
oh noes! by Erk December 16, 2004
The expression, gesture or sound of someone's sexyness or misfortune.
Oh Noes! He is sexier than me.
Oh Noes! I am a sexy beast.
Oh Noes! by Consta June 14, 2005
Used when something that happens that is the worstest thing that could ever happen, seemingly.
When Darth Vader tells Luke Skywalker he is his Father.

Darth: "Luke, I am your father!"
Luke: "Oh Noes!"
oh noes by JagShrapnel November 24, 2006
Something you say when the FBI or the police are at your door, and they are after your LUNIX.

Casual use can be caused by a combination of displeasement and fear for Microsoft lawsuits against open source operating systems, such as Redhate Lunix. It may include other, less important things.
JeffK: "Oh noes, teh police! HIDE TEH LUNIX!!!11"

"Oh noes, I forgot to take your bro out of the oven!"
oh noes by Stasis AMK3 August 14, 2003