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Used when something that happens that is the worstest thing that could ever happen, seemingly.

When Darth Vader tells Luke Skywalker he is his Father.

Darth: "Luke, I am your father!"
Luke: "Oh Noes!"
by JagShrapnel November 24, 2006
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2
1) A response to a negative situation which is insignificant, or at worst, a temporay inconvenience.

2) A response to a negative situation occurs on a regular basis, to the point where it is expected.
Guy A: "Aw, man, the Marlins lost"
Guy B: "Oh noes!"

Guy A: "Windows crashed again."
Guy B: "Oh noes!"
by Master Grah April 30, 2008
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4
An exclamation of horror and shock, negatively looking at an outcome.
<kid 1> I beat up your little brother, stole his lunch money, and hung him by his neck over a fiery pit of doom.
<kid 2> Oh no!
by Alanax0rz May 23, 2004
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5
Something you say when the FBI or the police are at your door, and they are after your LUNIX.

Casual use can be caused by a combination of displeasement and fear for Microsoft lawsuits against open source operating systems, such as Redhate Lunix. It may include other, less important things.
JeffK: "Oh noes, teh police! HIDE TEH LUNIX!!!11"

"Oh noes, I forgot to take your bro out of the oven!"
by Stasis AMK3 August 14, 2003
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7
Saying "oh no" in a more meaningful or comical way.
My friend nailed this chick but then her father came in he was like, "oh nos..."
by Boady May 23, 2007
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