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1) A response to a negative situation which is insignificant, or at worst, a temporay inconvenience.

2) A response to a negative situation occurs on a regular basis, to the point where it is expected.
Guy A: "Aw, man, the Marlins lost"
Guy B: "Oh noes!"

Guy A: "Windows crashed again."
Guy B: "Oh noes!"
by Master Grah April 30, 2008
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2
Used when something that happens that is the worstest thing that could ever happen, seemingly.

When Darth Vader tells Luke Skywalker he is his Father.

Darth: "Luke, I am your father!"
Luke: "Oh Noes!"
by JagShrapnel November 24, 2006
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3
Like oh no, but when you say it so fast that it blends together. Typically used when reacting to horrifying or disappointing events.
TV Host: Mike, the results of your DNA test are in. You are the father.

Mike: ohno ohno ohno
by sukeban March 02, 2019
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4
An exclamation of horror and shock, negatively looking at an outcome.
<kid 1> I beat up your little brother, stole his lunch money, and hung him by his neck over a fiery pit of doom.
<kid 2> Oh no!
by Alanax0rz May 23, 2004
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6
Something you say when the FBI or the police are at your door, and they are after your LUNIX.

Casual use can be caused by a combination of displeasement and fear for Microsoft lawsuits against open source operating systems, such as Redhate Lunix. It may include other, less important things.
JeffK: "Oh noes, teh police! HIDE TEH LUNIX!!!11"

"Oh noes, I forgot to take your bro out of the oven!"
by Stasis AMK3 August 14, 2003
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7
When you're too lazy to put a space between oh and no
Friend: "I hat you!!1!"
Other person: "ohno!"
Friend: "um wat?"
Other person: "I was being lazy.."
Friend: "oh..."
by Weeeeee Wooooooo June 26, 2018
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