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The couple Callie/Arizona from the fictional hit drama, Grey's Anatomy. The couple is currently the only lesbian couple on primetime television. The characters are portrayed as Sara Ramirez (Callie) and Jessica Capshaw (Arizona).
"Did you watch Grey's last night?"
"YES! Calzona broke up."
"It's okay though, they're MFEO.
Calzona by Jasmine9 November 28, 2010
Callie & Arizona of Grey's Anatomy. They are currently the only fictional lesbian relationship on network TV. (Feb. 2010)
Natasha only watches Grey's for the CalZona scenes.

Sami Riot doesn't care for CalZona, but Natasha loves her anyway<3
CalZona by Nati J February 5, 2010

flaming calzone 

slang; disparaging and offensive; a derogative term originated from western Massachusetts which implies a male homosexual who likes to order homoerotic food
Cory was creeping around on the phone for a very long time. It's possible he was talking to a flaming calzone for dinner.
flaming calzone by puffton pikachu September 7, 2011

Calzone._.zone 

Holy fucking shit lois how many times do I have to tell you, I am NOT going to install counter strike global source. FUCK OFF *beats her ass*
Calzone._.zone is just cooler than you are, dipshit *spits on you*

moist calzone 

Is basically an overly wet gross pussy, gots aids. Best way to describe your mom
"I would Fuck Jenny but I heard she has a moist calzone"

calzone effect 

When your buddie orders a calzone delivered to your house and then you order one within an hour causing the calzone effect to take place
I ordered a calzone because of the calzone effect