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Albert Wesker 

In simplified terms, Wesker is a badass who wears sunglasses all the time and uses a ton of hair gel in the Resident Evil video games.
Albert Wesker's badassery is amplified by the fact he wears sunglasses at night. Because only the badassiest of the badassiest do that.
Albert Wesker by vaati000 October 18, 2008
Resident Evil 5 villian that will totally kill you. So stay away, and button mash fool. Should also be used as a verb.
Man, did you see that headshot? I totally Weskered his face off.
Wesker by Zaynica June 23, 2009

Pulled a Wesker 

When someone mysteriously or abruptly vanishes as if without a trace. Referencing the actions of the character Albert Wesker in the first Resident Evil game.
Hey Mike, gave you seen Gary? He was here a minute ago.

Shit man, I think he pulled a Wesker.

Albert Wesker 

The muthafucka that is hard as hell to kill on Resident Evil 5.
"Ive been playing this level all fucking day and I still can beat Albert Wesker!!"
Albert Wesker by DezzT February 25, 2010

Albert Wesker 

Badass villain from the Resident Evil series who wears sunglasses all the time and bitchslapped Claire Redfield. Wanted complete global saturation.
*Albert Wesker bitch slaps Claire Redfield* Ooh, Wesker knows how to treat the ladies!
Albert Wesker by DAT-ASS January 17, 2013

Albert Wesker 

The central villain of the Resident Evil series of video games. Albert Wesker was introduced as a secondary character in the original game, being the traitorous captain and founder of the Raccoon City Police Department's Special Tactics and Rescue Squad (S.T.A.R.S.) and was subsequently killed at the end of the game. Due to his unexpected popularity, Wesker was brought back in Resident Evil Code: Veronica as the new villain of the series, and it was discovered by the S.T.A.R.S. that he had caused everything from his own apparent "death" to the destruction of the Umbrella Corporation. He remains at large.
After a long search for their missing team mates, Barry and Jill had gone their seperate ways. Albert Wesker stayed, crouched in the balcony even after their departure, wondering how he could have let all of his careful planning fall to shit.
Albert Wesker by Harry Hastings August 6, 2006