Resident Evil 5 villian that will totally kill you. So stay away, and button mash fool. Should also be used as a verb.
Man, did you see that headshot? I totally Weskered his face off.
by Zaynica June 23, 2009
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A video game character from Resident Evil 5/Biohazard that will rip you a new one if you don't pay attention to the button mashing sequences.
DAYUUUMM WESKER DONE SNAPPED HIS NECK
by enitnelav llij May 25, 2009
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A name that belongs to the best dog that ever was. Originally given to give embodiment to a destructive little shit, it quickly became a name loved by everyone that met him. Truly, one that can and will always be called best friend.
Guy One: What's his name?
Guy Two: Wesker!
Guy One: Like the Resident Evil character?
Guy Two: Exactly! He chewed up all of my stuff, I figured the name would fit.
by TheBarghest July 20, 2019
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In simplified terms, Wesker is a badass who wears sunglasses all the time and uses a ton of hair gel in the Resident Evil video games.
Albert Wesker's badassery is amplified by the fact he wears sunglasses at night. Because only the badassiest of the badassiest do that.
by vaati000 August 30, 2008
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When someone mysteriously or abruptly vanishes as if without a trace. Referencing the actions of the character Albert Wesker in the first Resident Evil game.
Hey Mike, gave you seen Gary? He was here a minute ago.

Shit man, I think he pulled a Wesker.
by Cairns Chaos July 6, 2017
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The muthafucka that is hard as hell to kill on Resident Evil 5.
"Ive been playing this level all fucking day and I still can beat Albert Wesker!!"
by DezzT February 26, 2010
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Badass villain from the Resident Evil series who wears sunglasses all the time and bitchslapped Claire Redfield. Wanted complete global saturation.
*Albert Wesker bitch slaps Claire Redfield* Ooh, Wesker knows how to treat the ladies!
by DAT-ASS January 18, 2013
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