Either a general expression of exasperation about a deluged inbox, or a referent to the behaviour of online/content marketers who think people have nothing better to do than read the 7 e-mails they send every week that are 3 pages each in length, trying to peddle their wares or upsells.
When everything is just too extra to handle, it's just too much fucking effort, or simply: TMFE.
Student: I have to study for ReproBio, and I need to find a new boyfriend, and I also need to find a job for summer.
Friend: That's TMFE. Just #BailandSkye