When someone lies to you or does something lame, Ditches you, or is just straight up being gay.
when someone has you come over saying they have pizza and not have pizza its thrife. Or make up some lame excuse to why they cant hangout. Or when someone is just being straight up lame.
To engage in penetrative genito-genital or genito-anal sexual intercourse to climax three times, in fairly close succession (such that it can be considered one session or takes place over one night). Not necessarily interpreted literally, but rather used figuratively to emphasize the relative hot-ness of the act itself or the person(s) involved, i.e. not once, not twice, but thrice.
E.g.: "My God, I would thrice lay him!" or "You totally thrice laid my ex-..."
Originally appears in an exchange between Gandhi and Geldemore of Clone High - S01E09-- Geldemore: "... As a reward for your bravery and leadership, I shall thrice lay you." Gandhi: "Uhhh, that's—, that's cool. But {cough} I'm good."
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).