A blend of "pussy" and "frustrated", meaning very angry at your girlfriend because she broke up with you.
Ex1: Dude, my girl just ditched me. I’m so freaking pusstrated.
Ex2: Breaking up right before engagement could be very pusstrating.
Ex3: Come on man! Stop being pusstrated!
When you have to pee, but you are in a conversation with someone and over time you stop really paying attention - because your bladder has highjacked your brain.
The last 20 minutes of that meeting were useless for getting anything accomplished because I was so pisstracted.