Something you say to blow off a dude trying to pick you up at a bar. A portmanteau of pick-up and blow-off.
OMFG! This total loser was flirting with me and I just wanted him to shut the fuck up and I said "Sorry, I like boys with tattoos" then he shows me his back and he has a huge like artwork thing on the back! Worst pick-off line ever!
I had a great pick-off line the other day. I was like "sorry, dude. I'd love to talk to you more, but I have some over-ripe fruit at home and I'm itching to bake it into a pie."
A shortened version of "pick your shit up and get the fuck out", an insult similar to "Piss off" but with emphasis to the person's personal belongings and or problems.
Chunkytold George to Pick Off! when he was being rude and impolite.