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Permasmile 

Also known as perma-smile.

To have a permanent smile on your face when you are under the influence of any drug or alcohol. Most likely, somebody will have a permasmile when they are on really good shrooms and suffer from uncontrollable laughter that seems to go on forever.
I was so trashed last night on shrooms that I had a permasmile and thought everything was funny.
Permasmile by Citizen Insane January 2, 2005
Related Words

permagape 

When ones holes have been penetrated so many times they no longer shut
Anybody who goes to prison is now permagaped.
permagape by TheBootyMan November 18, 2014

permacast 

Perpetual gray skies, as those found in the Pacific Northwest, most notably Portland.
"By February, months of permacast had me needing to get out of Portland and find some sun."
permacast by spenceronehalf November 17, 2005

PermaNast 

Something has been so nasty for so long that even if you cleaned it, it would still be nasty.

Or something just happened that was so nasty, there can be no redemption.
1. I got this old cellphone, and I've cleaned it 4 times, but it still has bad breath smell and is greasy. It's PermaNast.

2. "I was brushing my teeth, and my toothbrush fell into the toilet instant PermaNast"

3. "can I borrow your keyboard? Bro, never mind there are fingernails in between the keys, PermaNasty ass"
PermaNast by Dutchmaster scott2 October 18, 2016
Bro 1: Did u see that new Katy perry video?

Bro 2: hell yea, had a pergasm.
pergasm by russelonthat June 13, 2011

Percogasm 

1. Reaching an orgasm while on a pain killer. 2. The use of a powerful pain killer to enhance the pleasure of cumming.
I had a Percogasm last night. It was okay.
Percogasm by the2ndflood December 9, 2007