When a person's face is so bloated and deformed that it's impossible to distinguish it from their ass. As it is, the ass already resembles a hippopotamus face. For the poor bastard sporting one of these, it also resembles theirs. It is a synonym with "Ed Zachary Disease".
Yikes - look at that double hippopotamus. If he ate with his ass and sat on his face, I wouldn't know the difference.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.