In Spanish it can mean two things, depending on which syllable is being stressed.
* está: literally means "is". It's used to refer to someone in third person, and to either describe this person or specify a location
* ésta: literally means "this". It always refer to a feminine subject.
In some latin american countries, the latter is also commonly used to to refer to one's genitalia, specifically (her/him)self's.
Variations of esta:
Maria: Juan está en su casa y está triste (Juan _is_ at his home and _is_ sad)
Luis: Espero que ésta sea la ultima vez. (I hope _this_ is the last time)
Mario: Por qué no venis y me chupas ésta? (Why don't you come and suck _this_?)
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).
Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.
After school, The Modells on Jamaica Ave was active. Respectfully.