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It is short for different but it can be used as an noun, adjective, or verb. It’s meaning can change and has to be interpreted with context.
“Damn, LeBron James is so good at basketball. He is deefér.”

Hey I’m thirsty, can you pass me that deefér.”

“I’m tired I need to go deefér”
Deefér by NNNDeefér September 5, 2019
Related Words
adverb. a synonym for the word definitely. used to express complete agreement or strong affirmation.
guy #2: dude you wanna come to my party, it's gonna be super sick!
guy #1: defferson!
Defferson by Brent Handles January 23, 2009
Some one who pretends their the shit. But every one knows they are not.
Man you say your so good at basketball but when I ask you to play your always to tired or hurt. Your nothing but a dewger.

That orig guy is such a dewger.
dewger by J2quared March 25, 2008

Dewfresher 

A fresh looking new haircut.

Dew - as in Hair"do".
Fresher - as in fresher than before.
Dude you should get a dewfresher.

Man thats a nice dewfresh.

That dewfresh is too fresh.
Dewfresher by Brodeur October 19, 2010

vas deferens 

the vein/tube that connects the testicles to the prostate gland, and then to the urethra to release semen.
(This IS a real word!)
If you cut off my vas deferens, I will never have babies!!
vas deferens by nasal puff December 28, 2005

Deefer Douchebag 

Someone exhibiting the qualities of a pansy, whiny ass bitch that thinks they are sweet at everything; Pretends to have many friends, but is unanimously hated.
"Man I hate that deefer douchebag. He really takes it hard in the ass."