This is what the lame people who think they are cool say, instead of the regular WTF. In reality, they are seeming more if they dropped out of 2nd grade and cannot spell worth a shit. Or should I say, "werth aye sheet"?
To be on one to the extreme, due to the effects of drinking 4Loko specifically, or any potent, high powered malt liquor beverage in general (ie; St. Ides, Old English, etc...).
"Did you see that foo in da club las' nite? Was he on one or what?"
"On one? Shiiit... That nigga was more than on one, he was 4 Lok'd da fuk out!"