Just generally trippin', tweakin', weird, actin' a fool, blackin' out, goin' off. Not necessarily due to drugs, though that's the obvious reference.
Homie was on one, just buggin' like I shot his mom or something.
by Kuahmel January 22, 2009
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to be under the influence of methamphetamines
i heard joe's been on one for the past three days
by Leya Fish January 19, 2003
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To be under the influence of methamphetamines AKA ice,meth,speed,dope,etc.
Tuttie's on one man, he been smokin' ice all week!
by rooster760 February 28, 2005
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Just broke up with my girl and this alone time has me feelin' on one right now.
by Fresh Livin' May 5, 2015
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to be high, faded, to have just smoked weed.
My man James was on one at the party.
by metalgearray February 20, 2005
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horny randy upforit madforit gaggingforit right-on-it etcetc
see above
by jeff May 4, 2003
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An informal code of street fighting, not allowing bystanders to interfere in the fight.
Hey bitch-ass, let's square it up one-on-one in the midldle of the street!
by PGrace August 4, 2003
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