Just generally trippin', tweakin', weird, actin' a fool, blackin' out, goin' off. Not necessarily due to drugs, though that's the obvious reference.
Homie was on one, just buggin' like I shot his mom or something.
by Kuahmel January 23, 2009
Get the on one mug.
to be under the influence of methamphetamines
i heard joe's been on one for the past three days
by Leya Fish January 20, 2003
Get the on one mug.
To be under the influence of methamphetamines AKA ice,meth,speed,dope,etc.
Tuttie's on one man, he been smokin' ice all week!
by rooster760 March 1, 2005
Get the on one mug.
Just broke up with my girl and this alone time has me feelin' on one right now.
by Fresh Livin' May 5, 2015
Get the on one mug.
to be high, faded, to have just smoked weed.
My man James was on one at the party.
by metalgearray February 20, 2005
Get the on one mug.
horny randy upforit madforit gaggingforit right-on-it etcetc
see above
by jeff May 4, 2003
Get the on one mug.
1. A game where the only opponents are two people playing against each other.
2. Also know as speedballing; a mixture of cocaine and herion, most often injected.
1. Jack says to Tommy, "Let's play a game of one on one"
2. After getting out of lock-up, I said to myself, "I'm 'bout ready to head downtown and gets me a one on one!!"
by dieselgirl August 7, 2003
Get the one on one mug.