Just generally trippin', tweakin', weird, actin' a fool, blackin' out, goin' off. Not necessarily due to drugs, though that's the obvious reference.

To be fucked up on whatever your drug of choice is. It is beyond just tipsy or lightheaded, it's full on faded/twisted/tweaked/trippin/high/etc.

Slang used to describe when someone is in a bad mood

to be under the influence of methamphetamines

Feeling way too good.

To be under the influence of methamphetamines AKA ice,meth,speed,dope,etc.

Mass consumption of alcohol/drugs. Going past the point of no return and coming back only to return again.
You might have been one one if:
Its 9am and you are lying naked in bed next to a 300 lb. Miami, who you have never met before, with a peculiar taste in your mouth.
You wake up in the drunk tank and you have been told you’re being booked for defecting on top of car in a shopping center parking lot in broad day light.