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Just generally trippin', tweakin', weird, actin' a fool, blackin' out, goin' off. Not necessarily due to drugs, though that's the obvious reference.
Homie was on one, just buggin' like I shot his mom or something.
by Kuahmel January 22, 2009
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May 11 Word of the Day
A euphemism for β€œkill me” now that composting oneself after one’s death has become popular.
All right, why don’t you just compost me?
by Dr Bunnygirl March 22, 2020
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2
To be fucked up on whatever your drug of choice is. It is beyond just tipsy or lightheaded, it's full on faded/twisted/tweaked/trippin/high/etc.
Damn, Rick James was on one back in the 80's.

That bum jackin off in the corner must be on one, damn tweak.
by Joe Blaze January 25, 2008
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3
to be under the influence of methamphetamines
i heard joe's been on one for the past three days
by Leya Fish January 19, 2003
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4
Slang used to describe when someone is in a bad mood
"Man, I dont know what Susans problem is but she's On one!"
"Yea she's been a crank lately"
by Aschattack June 02, 2018
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5
To be under the influence of methamphetamines AKA ice,meth,speed,dope,etc.
Tuttie's on one man, he been smokin' ice all week!
by rooster760 February 28, 2005
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6
Just broke up with my girl and this alone time has me feelin' on one right now.
by Fresh Livin' May 05, 2015
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