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anhedonia 

Noun. The inability to experience pleasure. adjective form: anhedonic.
I would commit suicide, but my anhedonia would prevent me from enjoying even *that*.
anhedonia by YourLordAndMaster December 23, 2003

Anhedonia 

The loss of interest and enjoyment in all activities that you once liked; the feeling of not caring anymore.
I have been feeling Anhedonia lately.
Anhedonia by cc707 January 26, 2021

anhedoniac

is one who suffers from anhedonia, the inability to derive pleasure from normal pleasurable things in life.
If someone is depressed, or has one of many different chemical imbalances in the brain.

-Comedians, for example, may be prone to having this, as what actually makes them laugh has been used so much, that that part of the brain has "worn off funny".
Funny incidents and stories are enjoyed less and less, as time goes on.
(Try telling a comedian a joke, any joke.)

A chronic masturbator has a dopamine imbalance, rendering him or her an anhedoniac, incapable of enjoying normal life in a non orgasmic state.

A person with multiple lovers/sexual partners in life cannot settle down to marry. The more they sample, the less they are able to settle, as a direct result of wanting something "strange" or "new" all the time.

Beautiful, rich people in Hollywood have, or can have anything, or everything, or almost any ONE they could ever want, anytime and all the time. Anhedonia from repeatedly fulfilling their desires is a forgone conclusion in some cases.

(In old school parlance, "too much of a good thing".)

(This may effect more people than we know as the pursuit of pleasure on this planet for it's own sake is rampant.)
e.g. "I can't WAIT for the weekend!"
anhedoniac by Omega Rat 1 August 26, 2009
A feeling of pain and pleasure at the same time.
Retart: yo dood do you know what sex feels like?

Retard2: I’m not sure since I’m a virgin but I’ve heard it’s algedonic
algedonic by Abound December 26, 2017

anhedonic 

anhedonic guy: this sucks
other guy: thats just because your anhedonic
anhedonic by tom bensley September 4, 2007

anhidonic 

anhidonic-cant enjoy anything
person-this isnt very fun...

person2-thats because your an anhidonic bastard!
anhidonic by tom bensley August 31, 2007