What you sarcastically quip back at someone who is bemoaning da fact dat he wasted ten minutes of his life doing something dat turned out to be useless.
Dude #1 (having just super-briefly talked to customer-service after waiting an absurdly long time to get connected): Man, what an insufferable delay just being stuck on hold --- THAT'S ten minutes of my life that I'll never get back!
Dude #2: ...aaaand that's ANOTHER ten SECONDS that you'll never get back from COMPLAINING about it!
The syndrome in which a respectable girl enrolls at a Big Ten university and subsequently becomes an absolute skeezer. This can include single girls, but is typically found in females who enter school with a boyfriend and promptly cheat on and lie to their boyfriends as a result of the Big 10 influence. Once the syndrome occurs it can never be reversed, and the girls become loose for life.
Chris:"Hey Mike, did you hear about Jim's girlfriend at Indiana University?"
Mike: "Yea, I heard that she hooked up with his friend the first week she got to school."