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Talking to My Nephew 

Masturbating, Jacking Off, Beating Your Meat.
Hey man, open the door. What are you doing in there?" "Get out of here man, I'm talking to my nephew.

My interest in what you are talking about is low to moderate. 

Quote from the popular web series 'The Guild'. To shorten it up, it just means 'I don't care'.
Adam: I need a mentor with a penis.

Krystyl: My interest in what you are talking about is low to moderate.

I'm taking my talents to south beach. 

Janette: So are you going out tonight?

Erica: Nah, I think I'll stay in - I'm taking my talents to south beach.

Taking My Talents to South Beach 

A euphemism for masturbation.

Derived from the much-hated Lebron James and his words to describe his departure from the Cleveland Cavaliers for the Miami Heat.
If anyone needs me, I'll be in my bathroom taking my talents to South Beach.

I'll be taking my talents to south beach. 

1. To inform someone that the current situation is no longer working.

2. Fuck off.

3. Your not doing it for me anymore, or what you offer is lacking.
The new "it's not me it's you" is "I'll be taking my talents to south beach."

"It wasn't working out so I told her 'I'd be taking my talents to south beach."

"My boss was giving me grief so I said, straight up 'I'll be taking my talents to south beach."

"You don't have kidney beans in this here general store?! Well f-that. I'll be taking my talents to south beach!"

"After the Rolling Stones article, President Obama told General McChrystal he could take his talents to south beach."

It originates when LeBron James turned down the Cleveland Cavaliers offer, on a 1 hour nationally televised special, expressing that he was signing with the Miami Heat. He said "This fall I am taking my talents to south beach."

I'm taking my talents to South Beach 

The act of going the bathroom, specifically for a shit. Comes from LeBron James using this phrase to take a massive shit on a huge number of people: fans, teammates, and the entire NBA.
Bro #1: It's time for that bitchin' party!

Bro #2: Yeah! One sec though, I'm taking my talents to South Beach first!