Muthafacko Share definition Flag The new, seemingly cool, pronunciation of "mother fucker". Stolen from the movie "Big Money Hustlas". That's my money, muthafacko. 'Sup, muthafacko? What are you muthafackos up to this fine afternoon? Muthafacko by dcomposed December 13, 2003 0 0 Get merch Get the Muthafacko mug. Buy Now — $32.95 See more merch