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Duff (D.U.F.F.) 

abv. for Designated Ugly Fat Friend; Term men use to describe a fatter, less attractive friend, a woman brings with her to a party or social gathering to make herself look better by comparison. In some cases the more attractive woman will not "put out" for any male, unless one of his friends "takes one for the team" and "hits" the Duff.
C'mon take one for the team and hit that Duff (D.U.F.F.), I'll buy you lunch tomorrow!

daffy'd up

'all my my crew daffy'd up'
daffy'd up by KROOK 1 April 10, 2009

Daffy'd up

Peckham slang most notably used by the rapper Giggs, meaning to wear all black, A reference to daffy duck's black feathers.
So who got ya? did ya see em?

nahh, they was all daffy'd up an shit!!
Daffy'd up by hoodstar197 April 8, 2009
When something goes horribly wrong, as in when Hillary Duff was given a recording contract.
1) Did you see that guy get hit by that truck? Man, that was duff'd.

2) That girl's face is duff'd.
duff'd by Mirage December 31, 2004
Duff'd (v) - The act of getting used and or manipulated by an attractive, mentally unstable person of the opposite sex. Unfortunately this includes an abundance of flirting, profound mixed messages, and sexual enuendos that don't actually lead to SEX, merely the illusion that it will. The Duff usually ends by the Duff-er getting back together with their original girl/boyfriend, leaving the duff-ee with a killer case of blue balls/dry-gina.
Man, I thought this relationship was going to go somewhere, but really I was just totally getting Duff'd!
Duff'd by DFaFH April 25, 2006
when ones pancreas explodes (from duff mckagan of guns n' roses)
dude i was wasted last night i fucked like 4 chinese prostetutes then my pancreas duff'd
duff'd by Caflisch22 May 5, 2006