An awesome combination of calling someone a piece of shit and a cunt. When used, it is often in a more joking and lighter fashion. It takes two big insults and makes it humorous, but still holds the vulgarity.
An unusually evil, insidious, or vindictive cunt, almost always referring to a female. Someone who engages in tremendously damaging and selfish actions that cause misery to those around her but often result in her own advancement.
My horrible boss is the cunt of misery--she hates everyone who doesn't agree with her bullshit ideas and kiss her ass.
An annoying situation. Something that happens which is not supposed to, or you knew it was going to happen and couldnt prevent it. It usually causes pain or grief, either physically of financially.