When you get clapped by some mastery 7 windshitting skank and you're staring at the kill feed wondering why you still play this game.
Support: "Yo wtf happened on mid?"
ADC (while feeding): "I dunno man."
Top: "He got Yoned."
Jungle: "We all got Yoned, team play was kinda-"
Literally everyone in /all chat: "Jungle Diff. Report for Griefing"
A Family-Rated descriptor of the pubic region of a human being. Applicable to either gender.
Grandpa : Hey Bobbie, I hear you had to visit the doctor yesterday. Is everything OK?
Grandson : I'm fine, Gramps, thanks for asking. It was just a little itch down yonder. A leftover gift from a girl I dated last week.
Grandpa: Oh, I see. You're taking me back to my youth, sonny.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).