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The Powerpuff Girls 

1) A series of sexual acts involving shit, Diet Coke and Mentos, cum, saliva, vomit, or a combination of each. If done in the right order, these sex acts (mainly Blossom) can severely damage a girl's vagina. For obvious reasons, they must be done in this order: Blossom, Bubbles, and Buttercup.

2) Blossom, Bubbles, and Buttercup. Created by Professor Utonium after he accidentally added Chemical X to his mixture of "sugar, spice, and everything nice" while trying to make the "perfect little girl." See their names for more info regarding the sex acts mentioned above.

3) An animated children's television franchise centered around the girls mentioned above.
1) Guy 1: I did the Powerpuff Girls with my sister last night
Guy 2: how was it?
Guy 1: FUCKIN' INCREDIBLE!

2) And so, once again, the day is saved thanks to the Powerpuff Girls!

3) Remember when The Powerpuff Girls was good? Pepperidge Farm remembers!

Powerpuff Girls

Sugar. Spice. And everything nice.

These were the ingredients chosen to create the perfect little girl.

But Professor Utonium accidentally added an EXTRA INGREDIENT to the concoction.... CHEMICAL X.

Thus, the POWERPUFF GIRLS WERE BORN!

Using thier ultra super powers,
BLOSSOM, BUBBLES, and BUTTERCUP have dedicated their lives to FIGHTING CRIME and the FORCES. OF. EVIL!!!

Basically.
"Holy cow, it's MoJo JoJo! Somebody call the Powerpuff Girls!"
Powerpuff Girls by ~JMan January 10, 2009

powerpuff presentation 

A powerpoint presentation containing lots of flashy animations, cool pictures, and all sorts of other snazzy gimmics, but almost entirely lacking in any real substance.
Didn't the VP's presentation just blow you away? I loved the falling apples turning into dollar bills.

But what was the point?

Dunno; it was definitely a powerpuff presentation.

Powerpuff Girls Z 

A 2006 Japanese anime spin-off of the original American Show "The Powerpuff Girls". This anime was drawn by the same artists who worked on the Sailor Moon series. The anime is also produced by Cartoon Network, Toei Animation, and Aniplex even though the creator of the original show (Craig McCracken) did not take any part in this.The anime aired in Japan on July 1, 2006 and has yet to come to the U.S. or any other countries for that matter, but Cartoon Network said that the anime will be aired worldwide. The Ocean Group announced that they will dub the anime into English but they are not sure if it's going to make it to american television, or if the voice actors from the original show will voice act for the anime.
Powerpuff Girls Z is a pretty good, for a spin-off of an original show.

Powerpuff Girls

Best show ever. 'Nuf said.
Powerpuff Girls by Vanessa December 10, 2004

The Powerpuff Girls 

Sugar. Spice. And everything nice.

These were the ingredients chosen to create the perfect little girl.

But Professor Utonium accidentally added an EXTRA INGREDIENT to the concoction.... CHEMICAL X.

Thus, the POWERPUFF GIRLS WERE BORN!

Using thier ultra super powers,

BLOSSOM, BUBBLES, and BUTTERCUP have dedicated their lives to FIGHTING CRIME and the FORCES OF EVIL!!!
Person 1: hey bro, what do the Powerpuff Girls do?
Person 2: They fight crime and the forces of evil!!!!!