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The supreme leader of the satanist cults at the back of every classroom.
Cultist 1: Oh great On-On, what requireth you today?
On-On: I require 15 sacrifices of blood. Mwahahahahha!
On-On by A_Manwithhiv January 24, 2022
Just generally trippin', tweakin', weird, actin' a fool, blackin' out, goin' off. Not necessarily due to drugs, though that's the obvious reference.
Homie was on one, just buggin' like I shot his mom or something.
on one by Kuahmel January 23, 2009

five-on-one 

another definition for yankin your crank
My girlfriend wouldn't put out again so I had to go play some five-on-one.
five-on-one by Doyle November 14, 2003

five on one 

A slang word for male masturbation. It refers to your 5 finers on your penis, hence 5 on 1.
Hey man, i'm horny, i think i'm gonna go do a lil 5-on-1.
five on one by The Pimp February 3, 2003

Sneak up on one cheek 

To discreetly fart while in a crowded place.
"If I sneak up on one cheek, hopefully no one will hear me fart."
Sneak up on one cheek by creedmoor November 22, 2004

going off on one 

Idiom (UK), see go off on one. To launch into a rant or lengthy discussion about some pet subject.

Might be derived from "going off on a tangent", but has more of a connotation of annoyance.
Sorry for going off on one, but I really feel strongly about this.
going off on one by Cedders March 13, 2011