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1.To be high on stimulants like Meth or coke.
2.To work obsessively or compulsively on something.
3.To adjust something.
4.To be way wrong about something
1.He did 4 fat ass lines, hes tweakin hard
2.I was tweakin on my room for like 4 hours
3.I was just Tweakin the carb on my truck
4.you think the Boston Celtics are the best team ever..man your tweakin.
by Steve_Juggernaut April 28, 2006
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Boy 1: "Which came first the chicken or the egg?"
Boy 2: "Boi, what the.."
Boy 1: "My fault I'm tweakin"
by Giddy April 24, 2005
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(v) To be high on amphetamine.
"We be tweakin, like every single weekend, we be tweekin."

"Last night I danced for 10 hours, I was tweakin hard."
by saeed October 20, 2003
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Acting senseless or saying random things for no apparent reason or either under the influence of marijuana.
"Man, Janet is high and she tweakin' hard."
by THA.ONE April 30, 2009
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1) to be high on stimulant supplements(vitamins) or drugs.

2) to be hyperactive.
1) sugar, caffeine, monster drinks, sugar, earl gray tea, amphetamine, methamphetamine are examples of commonly used stimulants that can cause a person to be tweakin. They can become fast-moving, jittery and if on meth violently jumpy or shaky (trembling)

2) ADD/ADHD, natural high, sugar high, caffeine high can cause tweakin (hypetactivity) where you'll just be all over t he place moving fast.

when someone is hyperactive it doesnt mean they are under the influence of methamphetamine where meth high causes similar behaviour but is a different kind of hyper.
by skaterjack October 06, 2006
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