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It means uncle, although in anime character regularly use it in its less formal form where it functions more as "mister" or "sir." It's just an informal, but not necessarily rude, way to refer to an older man than yourself that you're unfamiliar with.

That's all I wanted to get clear. Most definitions stop at uncle and barely explain the secondary, and probably more common, use for it. "Ojisan" always means "sir/mister" unless they're actually they're uncle.
"You dropped your wallet, Ojisan" = "You dropped your wallet, mister/sir."
Ojisan by i8toast7 November 16, 2018
Related Words
oenis:
A viral infection which causes the penis to turn into an O. The viral infection is contracted and spread through sexual contact with an infected individual. Symptoms may include swelling of the genitals, course reddish bumps, discoloration of the genitals, and a burning sensation while urinating.
A week after a "study session" with AOD, Jimmy consulted his doctor and found out there was no cure for his oenis.
oenis by Undariaus November 14, 2007
Japanese for Uncle. Not to be confused with Ojiisan, which means Grandpa.
My Ojisan is going bald.
My Ojiisan is going short.
Ojisan by Spazmatik Illusion January 18, 2006
Ojisan literally means Uncle in Japanese.

Can also be used as a slightly impolite way to address a middle aged man, similar to the English "Mister".
My Ojisan is visiting from Osaka tomorrow.

Excuse me Ojisan, which train goes to Kyoto?

Hey Ojisan, keep your hands off my girl.
Ojisan by DicemanLucky7 June 23, 2008
Don't know what it means other than it's a typo of penis.
"Oenis."
"Thanks."
"No problem, enjoy your oenis."
"wut"
Oenis by orcabeau February 24, 2022
Fucker who cant spell “penis” right
HEY MAN YOU HAVE A BIG OENIS

WHAT THE FUCK
Oenis by 1ofthemqueers October 2, 2022