It means uncle, although in anime character regularly use it in its less formal form where it functions more as "mister" or "sir." It's just an informal, but not
necessarily rude, way to refer to an older man than yourself that you're unfamiliar with.
That's all I wanted to get clear. Most
definitions stop at uncle and barely explain the secondary, and probably more common, use for it. "Ojisan" always means "sir/mister" unless they're actually they're uncle.