The nyquist frequency is the number of times that a sound wave has to be sampled digitally in order to reproduce it accurately. The minimum is usually twice the highest frequency to be reproduced.
Akin to robotripping, NyQuilshuffling is the abuse of the cold medicine NyQuil in order to become intoxicated. Vaguely described in the song by They Might Be Giants, AKA Driver.
John: Dude, is Bob over there Robotripping?
Steve: No, he's NyQuilshuffling. You should probably confiscate his car keys.