In a tabletop game, a murderhobo is a player who murders NPCs indiscriminately. This is normally derogatory, referring to a player who totally ignores quests, dialog, backstory, trade, world building etc.
The term is most common with Dungeons and Dragons, but it can be applied to most RPGs where the player is allowed to kill most quest-giving NPCs and NPC traders. E.g. Elder Scrolls, Fallout, Divinity original sin.
DM: The sad little orphan girl tugs at Steve's trenchcoat to get his attention, and ask for help saving her pet dog from...
Steve: I'd like to roll a strength check against strangling the orphan.
Dave: I call dibs on the dog.
DM: You murderhobos disgust me.
What some Minnesotans call Minneapolis. Nickname originated in 90's when some areas of Minneapolis (Phillips Neighborhood etc.) had one of the highest number of homocides per squareblock in the US.
The typical protagonist of a fantasy role-playing game, who is a homeless guy who goes around killing people and taking their stuff. The term originated in discussions of tabletop role-playing games by authors seeking to create games aimed at styles of play not supported by traditional games like Dungeons & Dragons.
Four murderhoboes burned down the peaceful orc village, killed every orc in it, and looted their corpses.