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1. A kick ass nickname for a girl named Mary(or a boy, I don't judge). Usually thought of by their awesome friends. Eventually mayray will become their new name, it's unavoidable. The nickname will branch off into other names and songs about the nickname.

2. The effect of nickname making a person extremely popular or well known because of it
"Wow what happend to Peter, he was a total nobody last year"

"The mayray effect is happening to him. His new name has everybody talking about him."
by Justarandompersonontheinterweb November 26, 2013
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