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knuckle-up 

An action akin to the high-five or the handshake. The act of touching fists knukle-to-knuckle in greeting or departure. In 2003 this action was accompanied by the phrase "knuckle-up" but has since just become the motion without the phrase. The first instance of this action and phrase was in Dallas, TX in the mid-90's and has since become a common gesture in most public forms of transit in NYC.
Jimbo-- "Is that some kind of a gang sign?"
Miguel--"Nah, that's a knuckle-up, bro."
knuckle-up by super steve September 11, 2005
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Knuckle Up

To prepare to kick another's ass, getting prepared to engage in fisticuffs
If you get up in my grille, you best knuckle up, motherfucker
Knuckle Up by stefanali pops September 26, 2005

knuckle up

a phrase uttered in encouragement meaning: "muster your courage, intestinal fortitude and love for the American-way in preparation for an upcoming (or admist a) challenge
of epic proportions!"
(uttered many times by one of the dudes in the movie "The Matrixs:Revolutions" during battle
against the electro-mechanical foe)
"Here they come boys ... Knuckle up!"
knuckle up by abc July 13, 2004

Knuckle Up!

To Make Reddy, To Make Preparation, To Assemble, To Focus on the objective, To concentrate
Tomorrow's the big day people, there's no room for mistakes, so all of you better Knuckle-Up!
Knuckle Up! by ElkarO November 5, 2003

knuckle up

to prepare to fight.
Guy 1 "i was at the bar chillin talkin to this girl after the band played, then this dude looked at me like he wanted a problem."

Guy 2 "what happened?"

Guy 1 "I had to knuckle up then his boy pulled him back."
knuckle up by J Fri May 11, 2008

knuckle up

TO Put Up YOUR Setz And get ready to fight
knuckle up by shane June 18, 2003

Knuckle Up

The Act Of Whupping Someone's Ass!
BITCH All In My FACE We Bout 2 KNUCKLE UP In Did Bitch!!!